Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/47445
Title: Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
Authors: Wu, Bin
Keywords: RNTU::Science::Biological sciences
Issue Date: 2009
Source: Wu, B. (2009). Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The nucleosome is an essential structural and functional feature of eukaryotic chromatin, which allows for hierarchical genomic regulation. Not only are histones heavily involved in genomic events, nucleosomal DNA is found to possess structural characteristics important for genomic function as well. The discovery of chromatin site-selective compounds could allow targeting of specific genes, which coincide with weak points of cancer cells.
Description: 149 p.
URI: https://hdl.handle.net/10356/47445
DOI: 10.32657/10356/47445
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
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