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https://hdl.handle.net/10356/47445
Title: | Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction | Authors: | Wu, Bin | Keywords: | RNTU::Science::Biological sciences | Issue Date: | 2009 | Source: | Wu, B. (2009). Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | The nucleosome is an essential structural and functional feature of eukaryotic chromatin, which allows for hierarchical genomic regulation. Not only are histones heavily involved in genomic events, nucleosomal DNA is found to possess structural characteristics important for genomic function as well. The discovery of chromatin site-selective compounds could allow targeting of specific genes, which coincide with weak points of cancer cells. | Description: | 149 p. | URI: | https://hdl.handle.net/10356/47445 | DOI: | 10.32657/10356/47445 | Schools: | School of Biological Sciences | Rights: | Nanyang Technological University | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Theses |
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SBS_THESES_16.pdf | 21.37 MB | Adobe PDF | View/Open |
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