Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction.
Date of Issue2009
School of Biological Sciences
The nucleosome is an essential structural and functional feature of eukaryotic chromatin, which allows for hierarchical genomic regulation. Not only are histones heavily involved in genomic events, nucleosomal DNA is found to possess structural characteristics important for genomic function as well. The discovery of chromatin site-selective compounds could allow targeting of specific genes, which coincide with weak points of cancer cells.
Nanyang Technological University