Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/47447
Title: | Thioacid synthesis and application in peptide and protein chemistry | Authors: | Zhang, Xiaohong | Keywords: | DRNTU::Science::Biological sciences::Biochemistry | Issue Date: | 2009 | Source: | Zhang, X. (2009). Thioacid synthesis and application in peptide and protein chemistry. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | There is an increasing need for the use of synthetic proteins in biomedical research and drug discovery. Since its introduction in 1963, solid phase peptide synthesis (SPPS) has been widely used for the synthesis of peptides and small proteins. In recent years, convergent strategies for protein synthesis have been developed including Kemp's prior thiol capture ligation, thiazolidine-capture ligation, thioester-mediated native chemical ligation, thioacid capture ligation, followed by Staudiger ligation and decarboxylative condensation. Among them, the thioacid capture ligation is probably the most efficient in terms of reaction rate. The main reason for the low use of this method is the difficulty in obtaining the thioacid building blocks. | Description: | 156 p. | URI: | https://hdl.handle.net/10356/47447 | DOI: | 10.32657/10356/47447 | Schools: | School of Biological Sciences | Rights: | Nanyang Technological University | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
SBS_THESES_18.pdf | 15.78 MB | Adobe PDF | View/Open |
Page view(s) 10
878
Updated on Mar 19, 2024
Download(s) 5
494
Updated on Mar 19, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.