Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/47447
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dc.contributor.authorZhang, Xiaohongen
dc.date.accessioned2011-12-27T08:18:07Zen
dc.date.available2011-12-27T08:18:07Zen
dc.date.copyright2009en
dc.date.issued2009en
dc.identifier.citationZhang, X. (2009). Thioacid synthesis and application in peptide and protein chemistry. Doctoral thesis, Nanyang Technological University, Singapore.en
dc.identifier.urihttps://hdl.handle.net/10356/47447en
dc.description156 p.en
dc.description.abstractThere is an increasing need for the use of synthetic proteins in biomedical research and drug discovery. Since its introduction in 1963, solid phase peptide synthesis (SPPS) has been widely used for the synthesis of peptides and small proteins. In recent years, convergent strategies for protein synthesis have been developed including Kemp's prior thiol capture ligation, thiazolidine-capture ligation, thioester-mediated native chemical ligation, thioacid capture ligation, followed by Staudiger ligation and decarboxylative condensation. Among them, the thioacid capture ligation is probably the most efficient in terms of reaction rate. The main reason for the low use of this method is the difficulty in obtaining the thioacid building blocks.en
dc.rightsNanyang Technological Universityen
dc.subjectDRNTU::Science::Biological sciences::Biochemistryen
dc.titleThioacid synthesis and application in peptide and protein chemistryen
dc.typeThesisen
dc.contributor.supervisorLiu Chuan Faen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en
dc.identifier.doi10.32657/10356/47447en
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