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Title: Thioacid synthesis and application in peptide and protein chemistry
Authors: Zhang, Xiaohong
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2009
Source: Zhang, X. (2009). Thioacid synthesis and application in peptide and protein chemistry. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: There is an increasing need for the use of synthetic proteins in biomedical research and drug discovery. Since its introduction in 1963, solid phase peptide synthesis (SPPS) has been widely used for the synthesis of peptides and small proteins. In recent years, convergent strategies for protein synthesis have been developed including Kemp's prior thiol capture ligation, thiazolidine-capture ligation, thioester-mediated native chemical ligation, thioacid capture ligation, followed by Staudiger ligation and decarboxylative condensation. Among them, the thioacid capture ligation is probably the most efficient in terms of reaction rate. The main reason for the low use of this method is the difficulty in obtaining the thioacid building blocks.
Description: 156 p.
DOI: 10.32657/10356/47447
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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