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Title: Functional characterization of protein kinase NLK (nemo-like kinase)
Authors: Chan, Aye Thu
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2011
Source: Chan, A. T. (2011). Functional characterization of protein kinase NLK (nemo-like kinase). Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Nemo-like kinase (NLK) is a species conserved serine/threonine kinase that belongs to the mitogen activated protein kinases (MAPKs) and cyclin-dependent kinases (CDKs) families. TAK.1 (Transforming Growth Factor-beta activated protein kinase) acts as the upstream kinase of NLK and regulates the function of NLK in multiple signaling pathways such as Wnt-1, IL6 and TGF0. The preliminary findings of my research work highlight the versatile function of NLK because of its substrates that range from adaptor proteins like TAB2/3 (TAK1 binding protein 2/3) to transcriptional factors like c-jun (Activator protein 1 or AP-1) in the same signaling pathway to regulate TAK1 mediated signaling.
Description: 145 p.
DOI: 10.32657/10356/47448
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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