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https://hdl.handle.net/10356/47448
Title: | Functional characterization of protein kinase NLK (nemo-like kinase) | Authors: | Chan, Aye Thu | Keywords: | DRNTU::Science::Biological sciences::Biochemistry | Issue Date: | 2011 | Source: | Chan, A. T. (2011). Functional characterization of protein kinase NLK (nemo-like kinase). Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | Nemo-like kinase (NLK) is a species conserved serine/threonine kinase that belongs to the mitogen activated protein kinases (MAPKs) and cyclin-dependent kinases (CDKs) families. TAK.1 (Transforming Growth Factor-beta activated protein kinase) acts as the upstream kinase of NLK and regulates the function of NLK in multiple signaling pathways such as Wnt-1, IL6 and TGF0. The preliminary findings of my research work highlight the versatile function of NLK because of its substrates that range from adaptor proteins like TAB2/3 (TAK1 binding protein 2/3) to transcriptional factors like c-jun (Activator protein 1 or AP-1) in the same signaling pathway to regulate TAK1 mediated signaling. | Description: | 145 p. | URI: | https://hdl.handle.net/10356/47448 | DOI: | 10.32657/10356/47448 | Schools: | School of Biological Sciences | Rights: | Nanyang Technological University | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Theses |
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SBS_THESES_2.pdf | 14.92 MB | Adobe PDF | View/Open |
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