dc.contributor.authorLi, Hao.en_US
dc.date.accessioned2011-12-27T08:30:38Z
dc.date.accessioned2017-07-23T08:43:27Z
dc.date.available2011-12-27T08:30:38Z
dc.date.available2017-07-23T08:43:27Z
dc.date.copyright2010en_US
dc.date.issued2010
dc.identifier.citationLi, H. (2010). Part I : Cascade reaction, Part II : Synthetic studies of cytochalasans. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/47501
dc.description211 p.en_US
dc.description.abstractMukaiyama-Aldol and Prins reactions have been testified as highly efficient methods in C-C bond formation since they were discovered several decades ago. Since both reactions gave the same common intermediate, called oxocarbonium II, we intend to combine the two reactions into a domino process, which means the formation of multiple C-C bonds and stereogenic centers in one pot without isolation of any intermediates. We envisage that the domino reactions involving the Mukaiyama-Aldol reaction of silyl enol ether III and acetal I treated with Lewis acid (e.g. TiBr4) will produce an oxonium intermediate IV which upon trapping by an alkene functionality in an intramolecular Prins cyclization fashion will generate the cyclopentyl ring system VI (path a).en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Scienceen_US
dc.titlePart I : Cascade reaction, Part II : Synthetic studies of cytochalasans.en_US
dc.typeThesisen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.contributor.supervisorLoh Teck Peng (SPMS)en_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SPMS)en_US


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