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Title: Part I: Development of a base-free methodology for the nh-catalyzed intermolecular stetter reaction Part II: Chiral anion mediated asymmetric stetter reaction
Authors: Choo, En
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2009
Abstract: We succeeded in developing a base-free methodology for the NHC-catalyzed intermolecular Stetter reaction by employing CsF as a dual Lewis acid/base activating reagent, achieving the desired 1,4-dicarbonyl structural scaffold under ultrasonication reaction condition. Generally, moderate to excellent yields were obtained. Yields were especially good when highly reactive Michael acceptors were employed in conjuction with an aromatic carbinol carrying electron withrdrawing subtituents.
Description: 118 p.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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