Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/47515
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dc.contributor.authorHo, Iek Vaen_US
dc.date.accessioned2011-12-27T08:32:02Z
dc.date.available2011-12-27T08:32:02Z
dc.date.copyright2010en_US
dc.date.issued2010
dc.identifier.urihttp://hdl.handle.net/10356/47515
dc.description82 p.en_US
dc.description.abstractA formal synthesis of (+)-Neopeltolide macrolactone system has been performed in a total of 14 steps with an overall yield of 6.3 %. The key steps include: 1. catalytic enantioselective copper-catalyzed 1, 4-conjugate addition of a methyl Grignard reagent to an a,(3-unsaturated ester in 95% d.e. and 35% yield ; 2. Indium-mediated Prins cyclization reaction between an aldehyde and a homoallylic alcohol to install the 2,4,6-trisubstituted tetrahydropyran moiety in 56% yield ; 3. A novel functional group conversion from an aliphatic dihalo to a ketone in 50% yield .en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Science::Chemistry::Organic chemistryen_US
dc.titleSynthetic studies towards the formal synthesis of (+)-Neopeltolideen_US
dc.typeThesisen_US
dc.contributor.supervisorLoh Teck Pengen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.degree​Master of Scienceen_US
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