Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/47588
Title: Construction of 2,6-trans pyrans via Prins cyclization and its application towards the total synthesis of methyl sarcophytoate
Authors: Hu, Xuhong
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2011
Source: Hu, X. H. (2011). Construction of 2,6-trans pyrans via Prins cyclization and its application towards the total synthesis of methyl sarcophytoate. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Prins cyclization reaction involving a homoallylic alcohol with aldehyde is one of the most efficient methods to synthesize tetrahydropyran rings. However, due to the strong 1,3-diaxial interaction, the 2,6-cis tetrahydropyran moiety was formed preferably in most cases. The emphasis of this thesis is focused on the evolution of a convenient catalytic Prins cyclization for the construction of 2,6-trans pyranyl motifs and its application towards the total synthesis of natural product.
URI: https://hdl.handle.net/10356/47588
DOI: 10.32657/10356/47588
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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