Construction of 2,6-trans pyrans via Prins cyclization and its application towards the total synthesis of methyl sarcophytoate.
Date of Issue2011
School of Physical and Mathematical Sciences
Prins cyclization reaction involving a homoallylic alcohol with aldehyde is one of the most efficient methods to synthesize tetrahydropyran rings. However, due to the strong 1,3-diaxial interaction, the 2,6-cis tetrahydropyran moiety was formed preferably in most cases. The emphasis of this thesis is focused on the evolution of a convenient catalytic Prins cyclization for the construction of 2,6-trans pyranyl motifs and its application towards the total synthesis of natural product.
DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis