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https://hdl.handle.net/10356/47588| Title: | Construction of 2,6-trans pyrans via Prins cyclization and its application towards the total synthesis of methyl sarcophytoate | Authors: | Hu, Xuhong | Keywords: | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis | Issue Date: | 2011 | Source: | Hu, X. H. (2011). Construction of 2,6-trans pyrans via Prins cyclization and its application towards the total synthesis of methyl sarcophytoate. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | Prins cyclization reaction involving a homoallylic alcohol with aldehyde is one of the most efficient methods to synthesize tetrahydropyran rings. However, due to the strong 1,3-diaxial interaction, the 2,6-cis tetrahydropyran moiety was formed preferably in most cases. The emphasis of this thesis is focused on the evolution of a convenient catalytic Prins cyclization for the construction of 2,6-trans pyranyl motifs and its application towards the total synthesis of natural product. | URI: | https://hdl.handle.net/10356/47588 | DOI: | 10.32657/10356/47588 | Schools: | School of Physical and Mathematical Sciences | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Theses |
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|---|---|---|---|---|
| TspmsG0702498A.pdf | 6.46 MB | Adobe PDF |  View/Open |
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