Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/48438
Title: Co-delivery of hydrophobic and hydrophilic drugs from erythrocyte-PLGA nanoparticles complex
Authors: Tan, Tabitha Su Teng.
Keywords: DRNTU::Engineering::Materials::Biomaterials
Issue Date: 2012
Abstract: This work reported the fabrication of a dual drug delivery system, where layer-by-layer polyelectrolyte-coated PLGA nanoparticles were attached onto the surface of erythrocyte via electrostatic attraction. PLGA nanoparticles were loaded with a model hydrophobic drug (ibuprofen) and coated with 3, 5 and 7 layers of polyelectrolyte. The coating successfully controlled the release of ibuprofen from PLGA nanoparticles while at the same time, rendered the PLGA nanoparticles with a positive surface charge which can bind to the erythrocyte having a negative surface charge. Besides this, the erythrocyte was also loaded with a model hydrophilic substance (FITC-dextran) and its release behavior was studied. Considering that the particles and RBCs behave as two independent systems, it was hypothesized that it is feasible to create a dual drug carrier that can carry both hydrophobic and hydrophilic drugs, at the same time. Circulation time of PLGA nanoparticles is also hoped to be enhanced by attachment onto the surface of erythrocyte.
URI: http://hdl.handle.net/10356/48438
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
MSE11-042.pdf
  Restricted Access
991.88 kBAdobe PDFView/Open

Page view(s) 50

264
checked on Oct 26, 2020

Download(s) 50

14
checked on Oct 26, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.