Role of distinct dendritic cell subsets in disseminated candidiasis.

Abstract

Candida albicans is a human commensal and an opportunistic pathogen causing disseminated candidiasis in the immunocompromised. The incidence of such cases has been growing and this is also associated with a rising incidence of antifungal resistance. This makes it imperative to find other avenues for treating and preventing the disease. By finding immune cells that play a role in host defense against C. albicans, we may discover potential targets for vaccination and other immunotherapies. In this study, acute disseminated candidiasis was examined in the mouse model. Using diphtheria toxin-mediated cell ablation, we found that the ablation of conventional dendritic cells and marginal metallophilic macrophages result in reduced infiltration of neutrophils in the spleen. This suggests that these cells play a role in the neutrophil response, which is known to be critical in controlling disseminated candidiasis.