Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/49483
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dc.contributor.authorNurul Dini Abdul Rahim.
dc.date.accessioned2012-05-21T02:09:55Z
dc.date.available2012-05-21T02:09:55Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10356/49483
dc.description.abstractNeurodegenerative diseases have been associated with high mortality rates but only few treatments are available. Parkinson’s disease (PD) is the 2nd most common age-related neurodegenerative disease, characterized by motor symptoms such as resting tremors, rigidity, and postural instability. Non-motor symptoms, which precede the motor symptoms, are frequently overlooked in PD patients. In particular, 40% of PD patients have experienced chronic pain though it is unexplained. While PD has been known to be sporadic in nature, the discovery of PD genes and recent research on environmental factors on PD show that the development of PD is likely to have multifactorial origin. In this study, we investigated the nociception response using the formalin test in LRRK2R1441G mice, which is a PD mouse model. The mice were also tested for motor deficits in the cylinder test and gait analysis. Additionally, mice were subjected to unpredictable chronic mild stress (UCMS) and were also tested for motor deficits to observe the effect of stress on these mice. Our results show that the LRRK2 transgenic mutant mice showed greater nociception response with age. LRRK2 mice showed no motor deficits in the gait analysis at a younger age but had age-dependent motor deficits in the cylinder test at 12 months old. Mice subjected to UCMS did not show any significant motor deficits but show premise that mice could develop the motor deficits earlier.en_US
dc.format.extent27 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Scienceen_US
dc.titleEffects of stress on a mouse model of parkinson's disease.en_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeBachelor of Science in Biological Sciencesen_US
dc.contributor.organizationNational Neuroscience Instituteen_US
dc.contributor.supervisor2Zoë Bichleren_US
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Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)
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