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Title: Drug release mechanisms from bioerodible polymers for stent application
Authors: Alexis, Frank
Keywords: DRNTU::Engineering::Materials::Biomaterials
Issue Date: 2005
Source: Alexis, F. (2005). Drug release mechanisms from bioerodible polymers for stent application. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine.
DOI: 10.32657/10356/5048
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Theses

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