Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/5048
Title: | Drug release mechanisms from bioerodible polymers for stent application | Authors: | Alexis, Frank | Keywords: | DRNTU::Engineering::Materials::Biomaterials | Issue Date: | 2005 | Source: | Alexis, F. (2005). Drug release mechanisms from bioerodible polymers for stent application. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine. | URI: | https://hdl.handle.net/10356/5048 | DOI: | 10.32657/10356/5048 | Rights: | Nanyang Technological University | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
MSE-THESES_14.pdf | 4.55 MB | Adobe PDF | ![]() View/Open |
Page view(s) 50
577
Updated on Jan 18, 2021
Download(s) 50
180
Updated on Jan 18, 2021
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.