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|Title:||Drug release mechanisms from bioerodible polymers for stent application||Authors:||Alexis, Frank||Keywords:||DRNTU::Engineering::Materials::Biomaterials||Issue Date:||2005||Source:||Alexis, F. (2005). Drug release mechanisms from bioerodible polymers for stent application. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine.||URI:||http://hdl.handle.net/10356/5048||Rights:||Nanyang Technological University||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MSE Theses|
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