Please use this identifier to cite or link to this item:
Title: Conjugation of antibody fragments to ferritin protein cage for targeted delivery to cancer cells.
Authors: Thinzar Win.
Keywords: DRNTU::Engineering::Chemical engineering
Issue Date: 2012
Abstract: Ferritin is engineered as a targeted carrier for therapeutic and diagnostic agents. It is a naturally occurring biomaterial and functions in iron homeostasis in various organisms. The ferritin in this study is a protein cage derived from an archaeon Archaeoglobus fulgidus with unique self-assembling properties and remarkable heat stability. Due to its proteinaceous nature, the A. fulgidus ferritin (AfFtn) contains readily available reactive moiety for functionalization with targeting ligands. In this study, we have coupled mutant A. fulgidus ferritin (AfFtn-AA) with single-chain variable fragment (scFv) antibody to the surface of the protein cage for targeting purpose.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Theses

Files in This Item:
File Description SizeFormat 
  Restricted Access
1.11 MBAdobe PDFView/Open

Page view(s) 20

Updated on Nov 30, 2020

Download(s) 50

Updated on Nov 30, 2020

Google ScholarTM


Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.