Three disparate studies on the CD18 integrin : expression and biological functions of the human CD18 integrin in health and disease
Cher, Bernard Toh Hui
Date of Issue2011
School of Biological Sciences
Three disparate studies relating to the CD18 integrin are described in this thesis. Firstly, a particularly elusive CD18 mutation in an Leukocyte Adhesion Deficiency Type I (LAD-I) patient was studied. Genomic DNA and cDNA from an LAD-I patient and her family was analyzed and characterized. This mutation was a gross deletion where the CD18 gene was truncated and joined to the next gene on the chromosome, PTTG1IP.