Please use this identifier to cite or link to this item:
Title: Prion diseases : a review.
Authors: Cheng, Jason Chang Lin.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2012
Abstract: Prion diseases are caused by a misfolded protein which have the uncanny ability to escape destruction by the immune system in vivo and autoclaving in vitro. The pattern of these diseases was so eccentric as it defied the central dogma of molecular biology, because these prion proteins were infectious and could multiply to greater amounts even though they lacked the genetic material of DNA and RNA. The impact from prion diseases is great, with sporadic outbreaks worldwide that affect human life and out animal livestock. Though the misfolded prion protein structure has been elucidated, much work is still required to determine the cellular pathogenesis and treatment of these prion diseases. Recent studies have given new insight into the disease, including interactions with a possible E3 ligase correlated to the spongiform pathogenesis and a possible anti-prion defence and clearance system. This present report reviews the history, the types of prion diseases, pathogenesis, emerging theories regarding prion strain-like behavior and propagation and possible treatments of prion diseases.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
  Restricted Access
Literature Review989.59 kBAdobe PDFView/Open

Page view(s) 50

checked on Oct 20, 2020

Download(s) 50

checked on Oct 20, 2020

Google ScholarTM


Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.