Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/52503
Title: Structural properties of DNA G-quadruplexes with applications in colloidal assembly
Authors: Vineeth Thachappilly Mukundan
Keywords: DRNTU::Science::Biological sciences::Biophysics
Issue Date: 2013
Source: Vineeth Thachappilly Mukundan. (2013). Structural properties of DNA G-quadruplexes with applications in colloidal assembly. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: G-quadruplexes are complex DNA structures formed by guanine rich sequences. Such structures have the potential to form in many important regions of the genome such as telomere ends, promoter regions of many oncogenes. They exhibit a wide range of topologies depending on the nature of the sequences. In this work, we studied a number of sequences with interrupted G-tracts which were thought to disfavor the formation of G-quadruplexes. We found that many of these sequences form G-quadruplexes defying conventional rules. This thesis also addresses micro-particle assembly using DNA. Magnetic micro-particles have been connected with DNA quadruplexes to form long chains. This is supplemented by a study of dissociation of these particle chains in the presence of quadruplex binding ligands
URI: http://hdl.handle.net/10356/52503
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

Files in This Item:
File Description SizeFormat 
Vineeth Thachappilly Mukundan.pdf
  Restricted Access
5.46 MBAdobe PDFView/Open

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.