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DC Field | Value | Language |
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dc.contributor.author | Khoo, Jasmine Ser Chin. | |
dc.date.accessioned | 2013-05-17T01:57:22Z | |
dc.date.available | 2013-05-17T01:57:22Z | |
dc.date.copyright | 2013 | en_US |
dc.date.issued | 2013 | |
dc.identifier.uri | http://hdl.handle.net/10356/52545 | |
dc.description.abstract | Pterygium is a common ocular surface disease characterized by centripetal invasion of the conjunctival epithelium onto the cornea. The disease has a wing-shaped phenotype accompanied by inflammatory infiltrate and accumulation of proteases and extracellular matrix components. S100A proteins are involved in activating the immune system, and previous studies have implicated S100A8/A9 in many ocular surface diseases such as meibomian gland dysfunction, dry eye, preservative induced epitheliopathy and chemical injury. Since a variety of matrix and inflammatory proteins are dysregulated in pterygium, in this thesis, I attempt to determine if S100A protein is a master regulator that triggers these changes by adding S100A8, A9 and heterocomplex S100A8/A9 to cultured conjunctival fibroblasts. A variety of transcript changes were examined. Inflammatory chemokine (Chemokine (C-X-C motif) ligand 1), matrix proteins (Vimentin, Biglycan, and Gelsolin), Annexin-A2, Thymosin beta-4 and Ras-related protein Rab 10 molecules known to be upregulated in pterygium, were found to be induced by S100A8, A9 and A8/A9.These genes are therefore possible downstream of S100A8/A9 in diseases. Chymase-1 and Serpin peptidase inhibitor, clade A member 1 (SERPINA1) are known to be downregulated in pterygium but are upregulated by S100A9 protein, suggesting presence of other disease pathways. Intervention in S100A proteins may be impactful on a wide variety of ocular surface diseases by reducing disease mediators. | en_US |
dc.format.extent | 43 p. | en_US |
dc.language.iso | en | en_US |
dc.rights | Nanyang Technological University | |
dc.subject | DRNTU::Science | en_US |
dc.title | S100A8 and A9 proteins regulate expression of key genes for inflammation and wound healing. | en_US |
dc.type | Final Year Project (FYP) | en_US |
dc.contributor.school | School of Biological Sciences | en_US |
dc.description.degree | Bachelor of Science in Biological Sciences | en_US |
dc.contributor.organization | Singapore Eye Research Institute | en_US |
dc.contributor.supervisor2 | Dr Louis Tong | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
Appears in Collections: | SBS Student Reports (FYP/IA/PA/PI) |
Files in This Item:
File | Description | Size | Format | |
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BS12-198.pdf Restricted Access | FYP thesis | 1.86 MB | Adobe PDF | View/Open |
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