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Title: The role of N-WASP in epithelial-to-mesenchymal transition.
Authors: Muhammad Hakimullah Mohamed Ikbar.
Keywords: DRNTU::Science
Issue Date: 2013
Abstract: Epithelial-to-Mesenchymal transition (EMT) is an essential program in development and has been implicated in cancer progression. Cancer cells in the primary tumours are postulated to undergo EMT that renders them with the capability to break free from the primary tumour and invade into distant organs. As such, Actin cytoskeleton remodelling is crucial to confer cells with mirgratory and invasive capabilities. Actin cytoskeleton regulation hinges on Actin Nucleation Promoting Factors, one of the most important being the Neural Wiskott-Aldrich Syndrome Protein (N-WASP). During EGF-induced EMT, N-WASP expression was downregulated which suggests an inhibitory role for N-WASP during EMT. However, knockdown and over expression of N-WASP in A431 cells seemed to repress EMT. Cell-cell junctions were also intact in these groups of cells. Hence, the findings of this study serve as a very basic framework for future works pertaining to the role of N-WASP in EMT. Nevertheless, this study might provide insights into the possible components of the actin cytoskeleton that could serve as anti-cancer targets.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

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