Development of high performance Fluoridated Hydroxyapatite coatings for biological applications

Abstract

This study indicates that incorporation of fluorine ions into HA lattice structure can benefit both the mechanical properties and in vitro biological properties of the coatings: with the incorporation of fluorine ions, the residual stress is significant reduced, while the adhesion properties and toughness are remarkably enhanced; the lowest solubility and the most positive stimulating effect (testing in acellular solutions and osteoblastic cell responses) are observed at a fluoridation degree of ~0.8-1.1, at which the coating takes the chemical formulation of Ca10(PO4)6(OH)1.2-0.9F0.8-1.1.