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Title: Genetic screening for molecules involved in dopaminergic neuron specification.
Authors: Koh, Venessa Sock-Kheng.
Keywords: DRNTU::Science
Issue Date: 2013
Abstract: Parkinson’s disease (PD) is a multisystem, neurodegenerative disorder that affects the entire central nervous system. At present, there is no absolute cure for PD due to the complexity of the disease and the inability to define the precise pathology of PD. In this project, we would be examining dopamine (DA) neurons using Drosophila melanogaster as a model system. We examined the climbing ability of the Drosophila as well as the development of the DA neurons in the adult fly brain. Among the 33 P-element insertion lines that we examined, we discovered that 17 lines presented a phenotype. We observed that 3 different DA neuron clusters, PPM3, PPL2 and VUM, are mostly affected by the mutation.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

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