Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/52944
Title: Gastric dysplasia : a clinical and pathological analysis.
Authors: Lee, Jocelyn Shi Ting.
Keywords: DRNTU::Science
Issue Date: 2013
Abstract: Introduction: The intestinal- type gastric cancer carcinogenesis pathway is a series of multistep histological events. Gastric dysplasia, a premalignant lesion, occurs just before gastric cancer develops. It is characterised by cytological and architectural changes. However, the distinction in the grade of dysplasia is somewhat controversial with different systems (Japanese and Western) in place and also due to inflammation and reactive changes. In the Vienna classification, dysplasia is grouped into low grade, high grade and indefinite. Changes are not clear cut and unequivocal in indefinite dysplasia. Aim: To investigate the (1) Incidence of dysplasia, including indefinite dysplasia (2) Follow- up progression of indefinite dysplasia (3) Histological criteria with progression of indefinite dysplasia Results: The risk of progression to gastric adenocarcinoma increases with increasing age and showed male biasness. Out of 74 indefinite cases, 16 (21.6%) showed progression of indefinite dysplasia (median age 61.5). The follow- up biopsy time showed statistical significance (p= 0.003) with the progression of indefinite dysplasia. However, clinical and histological features were shown to be independent risk factors. Conclusion: The shorter follow- up time seen in the progression of indefinite dysplasia can be indicative of high clinical suspicion, suggesting that patients should be kept under close surveillance to provide for an early therapeutic window.
URI: http://hdl.handle.net/10356/52944
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
ThesisFinal.doc
  Restricted Access
2.27 MBMicrosoft WordView/Open

Page view(s) 10

217
checked on Oct 31, 2020

Download(s) 10

8
checked on Oct 31, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.