dc.contributor.authorElavazhagan Murugan.
dc.date.accessioned2013-06-04T04:44:44Z
dc.date.accessioned2017-07-23T08:42:36Z
dc.date.available2013-06-04T04:44:44Z
dc.date.available2017-07-23T08:42:36Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.citationElavazhagan Murugan. (2012). A study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/53489
dc.description.abstractNaturally occurring enediynes are potent antibiotics produced by soil and marine microorganisms. Their robust antitumor activities and unique mode of action make them a significant topic of study. The synthesis of the enediyne products is initiated by a type I iterative polyketide synthase (PKS). In this project, we examine the structures and functions of the domains of CalE8, to demarcate the domains of the the iterative PKS from the biosynthetic pathway of the 10-membered enediyne calicheamicin in Micromonospora echinospora spp.en_US
dc.format.extent181 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleA study of the functional domains of the type I iterative polyketide synthase CalE8 in calicheamicin biosynthesis.en_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorLiang Zhao-Xunen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US
dc.identifier.doihttps://doi.org/10.32657/10356/53489


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