Development of a synthetic Osteo-Odonto-Keratoprosthesis (OOKP) device

Abstract

The cornea is an avascular, transparent, and the most anterior layer of the eye, where light penetrates to focus on the retina to create a visual perception. It is responsible for 2/3 of the refractive power of the eye. The corneal epithelium has a rapid cell turnover rate. The sloughing off of the superficial central corneal epithelial cells is constantly replenished by the growth of stem/progenitor cells through centripetal migration from the corneal limbus, a transition zone between the transparent cornea and the opaque sclera.