Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/54323
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dc.contributor.authorNg, James Shizhao.
dc.date.accessioned2013-06-19T03:16:21Z
dc.date.available2013-06-19T03:16:21Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/10356/54323
dc.description.abstractTaxol is one of the most important and active chemotherapeutic agents for clinical treatment of cancers (including ovarian, breast bladder, prostate, and lung cancers), since taxol is an anti-proliferative agent that inhibits cancer cell division. However, the separation from pacific yew trees is the major resource of taxol, which makes the price of taxol prohibitively expensive and unsustainable. Microbial fermentation for the production of taxol has received much attention in recently years. In this thesis, we will investigate the taxol biosynthesis pathways in plant cells, and implement the gene expression systems into yeast and/or E. coli cells as the host, achieving high production yield of taxol in microbe(s).en_US
dc.format.extent76 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Engineering::Bioengineeringen_US
dc.titleMetabolic engineering for the optimal production of Taxol (Paclitaxel) - an efficient anticancer drug (focusing on upstream pathways for isoprenoid accumulation).en_US
dc.typeThesis
dc.contributor.supervisorSong Hao
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.degree​Master of Science (Biomedical Engineering)en_US
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