dc.contributor.authorChua, Geok Lin
dc.date.accessioned2013-10-30T01:59:11Z
dc.date.accessioned2017-07-23T08:42:42Z
dc.date.available2013-10-30T01:59:11Z
dc.date.available2017-07-23T08:42:42Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.identifier.citationChua, G. L. (2013). Structures and interactions of the leukocyte-specific integrins cytoplasmic tails. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/54936
dc.description.abstractIntegrins are devoid of enzymatic activity but yet are involved in almost all aspects of mammalian physiology. Their unique bidirectional signal transduction property can enable them to continuously sense changes in their extracellular environment and respond rapidly through conformational changes that modulates their affinity for extracellular ligands. This continuous sense and response system mediated by integrin molecules is a quintessential property of the mammalian immune system, which requires leukocytes circulating in the high pressure enclosed blood vascular system to respond to minuscule changes in the release of cytokines during an immunological event. This process requires leukocytes to rapidly change from non-adhesive, symmetrical cells to highly adhesive asymmetric cells to attach to the vascular walls amid the high pressure blood flow, followed by progressive migration via adept modulation of specific integrins towards the site of injury.en_US
dc.format.extent224 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleStructures and interactions of the leukocyte-specific integrins cytoplasmic tailsen_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorSurajit Bhattacharyyaen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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