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Title: Quantitative analysis of neural stem cell growth and differentiation
Authors: Shvetha Sankaran
Keywords: DRNTU::Science::Biological sciences::Cytology
Issue Date: 2014
Source: Shvetha Sankaran. (2014). Quantitative analysis of neural stem cell growth and differentiation. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Neural stem cells (NSCs) are self-renewing, multipotent cells in the embryonic or adult brain that can give rise to neurons and glia. NSCs and neural progenitors (NPs) can be propagated in vitro through a natural 3-D culture system known as neurospheres. Here, I report the use of non-invasive image acquisition and processing techniques to gain insight into the 3-D architecture of the neurosphere, characterise neurosphere forming cells (NFCs), develop an imaging-based method to enrich for NSCs, and a high throughput screening (HTS) strategy to study the effects of drugs on NSCs/NPs.
DOI: 10.32657/10356/55362
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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