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https://hdl.handle.net/10356/55362
Title: | Quantitative analysis of neural stem cell growth and differentiation | Authors: | Shvetha Sankaran | Keywords: | DRNTU::Science::Biological sciences::Cytology | Issue Date: | 2014 | Source: | Shvetha Sankaran. (2014). Quantitative analysis of neural stem cell growth and differentiation. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | Neural stem cells (NSCs) are self-renewing, multipotent cells in the embryonic or adult brain that can give rise to neurons and glia. NSCs and neural progenitors (NPs) can be propagated in vitro through a natural 3-D culture system known as neurospheres. Here, I report the use of non-invasive image acquisition and processing techniques to gain insight into the 3-D architecture of the neurosphere, characterise neurosphere forming cells (NFCs), develop an imaging-based method to enrich for NSCs, and a high throughput screening (HTS) strategy to study the effects of drugs on NSCs/NPs. | URI: | https://hdl.handle.net/10356/55362 | DOI: | 10.32657/10356/55362 | Schools: | School of Biological Sciences | Organisations: | A*STAR Institute of Medical Biology | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Theses |
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Shvetha_thesis.pdf | 6.51 MB | Adobe PDF | View/Open |
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