Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/57407
Title: Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
Authors: Wong, Chee Chung
Keywords: DRNTU::Engineering::Nanotechnology
Issue Date: 2011
Abstract: Cell adhesion and detachment are crucial components in cancer spreading, which often leads to recurrence and death. In this work, the traction force generated by cancer cells during spreading, cytoskeleton disruption, and detachment was quantified through direct electrical measurements on a novel electromechanical platform, amenable to high-throughput. This platform is based on mechanical structures, built around standard silicon processes, in which silicon nanowires (NWs) were embedded as miniature sensing elements to measure the surface stress on the mechanical structures, thus enabling to monitor of the traction forces applied by the cells to substrate during spreading. The scope of this research spans four topics; namely the electromechanical characterization of silicon NWs, and more particularly harnessing the giant piezoresistance effect in NWs, the characterization of their response as surface stress sensors, and lastly applying NWs in mechanosensing.
Description: 154 p.
URI: http://hdl.handle.net/10356/57407
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Theses

Files in This Item:
File Description SizeFormat 
SCBE THESES_5.pdf
  Restricted Access
24.45 MBAdobe PDFView/Open

Page view(s) 10

225
checked on Oct 26, 2020

Download(s) 10

7
checked on Oct 26, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.