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|Title:||In vitro and in vivo studies of nanomicelles interaction with blood cells||Authors:||Ma, Lwin Lwin||Keywords:||DRNTU::Engineering::Materials||Issue Date:||2011||Abstract:||This project studied the fundamental relationships between polymeric micelle structures and their "stealth" properties, as estimated from both in vitro studies and in vivo data. Passive targeting is one of the approaches engaged in reducing the side effects of intravenous chemotherapy. One type of carrier used in passive targeting is a polymeric micelle; to date, there have been very few studies correlating micellar structures to in vitro uptakes by blood cells and in vivo blood lifetimes. In this project, we have studied 4 different types [made from triblock copolymers (ABA, BAB types), diblock copolymers (AB) and star-branched copolymers of poly (L-lactide) or PLA and Poly ethylene glycol or (PEG)] of micelles, all of which have differing conformations and concentrations of PEG molecules on the micellar outer shell. These micelles were characterized for their size distribution in water/plasma by techniques such as Cytoviva, Total internal reflection fluorescence (TIRF) and Malvern light scattering. X-ray Photoelectron Spectrosocopy was applied to analyze the surface composition while scanning electron microscopy (SEM) was employed to estimate the size and shape of the micelles.||Description:||211 p.||URI:||http://hdl.handle.net/10356/58042||Rights:||Nanyang Technological University||Fulltext Permission:||restricted||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MSE Theses|
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