Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/60590
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dc.contributor.authorYin, Zhan
dc.date.accessioned2014-05-29T01:25:05Z
dc.date.available2014-05-29T01:25:05Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10356/60590
dc.description.abstractThe hippocampus is essential to the spatial memory of both humans and animals. Recent studies have revealed that the activity-regulated cytoskeleton-associated protein (Arc) gene expression in the hippocampus is crucial for memory consolidation and synaptic plasticity. This study investigated the function of Arc in the hippocampus at the cellular level by injecting an Adeno-associated viral vector with small hairpin RNA against the Arc gene and green fluorescent protein into the CA1 region on the left or right side of a rat’s hippocampus. Results showed that Arc knockdown can destroy the formation of place fields or decrease the mapping accuracy. Moreover, the recall property of place cells was lost after knockdown. These results indicate that the Arc gene is critical for memory consolidation at the cellular level.en_US
dc.format.extent30 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.titleCellular mechanism of place cell activity in hippocampal CA1en_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeBachelor of Science in Biological Sciencesen_US
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Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)
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