Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/62107
Title: Palladium-catalyzed stereoselective glycosylation with glycal donors : novel strategies for the construction of diverse glycosidic linkages
Authors: Xiang, Shaohua
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Carbohydrates
Issue Date: 2014
Source: Xiang, S. (2014). Palladium-catalyzed stereoselective glycosylation with glycal donors : novel strategies for the construction of diverse glycosidic linkages. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Carbohydrates play essential roles in many complex biological processes and are readily available from a wide range of natural sources. The development of glycobiology science has stimulated the growth in demand for oligosaccharides and glycoconjugates in the last few decades. As such, the construction of glycosidic bonds has increased in significance. In this section, a brief introduction to glycosylation and some main factors that affect the stereoselectivity such as anomeric effect, solvent effect and neighbouring group participation are discussed. Besides that, selected well-designed strategies to achieve stereocontrolled glycosylation are also presented. Thereafter, the recent development of transition metal catalyzed glycosylation with glycosyl-type donor is summarized to provide a basic foundation for the extension of our work.
URI: http://hdl.handle.net/10356/62107
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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