dc.contributor.authorNg, See Liang
dc.date.accessioned2015-02-27T02:59:15Z
dc.date.accessioned2017-07-23T08:42:53Z
dc.date.available2015-02-27T02:59:15Z
dc.date.available2017-07-23T08:42:53Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationNg, S. L. (2015). Contribution of lung migratory dendritic cells to the generation of influenza immunity. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/62214
dc.description.abstractOwing to the functional heterogeneity of DCs in the lung, there is a need to unravel the in vivo contribution of various DC subpopulations to the generation of influenza immunity. Using our Clec9a-DTR and Clec4a4-DTR transgenic mouse models which allow us to specifically deplete CD103+ cDCs and CD24+CD11b+ cDCs respectively in the lungs, we aimed to study the biology of these DC populations using mouse-adapted influenza A virus strain H1N1/PR8. We found that ablation of these lung-derived DCs led to high sensitivity to infection and severe depletion of influenza-virus specific CD8 T cells in the lungs and more importantly the mechanisms contributing to the reduced number of these pulmonary T cells in Clec9a-DTR and Clec4a4-DTR mice were different. Concurrently our data highlighted the dispensability of these DCs in the formation of homosubtypic immunity, but, they were required for the efficacy of heterosubtypic immunity.en_US
dc.format.extent169 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleContribution of lung migratory dendritic cells to the generation of influenza immunityen_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorKlaus Erik Karjalainenen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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