Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/62943
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dc.contributor.authorZheng, Jieen
dc.date.accessioned2015-05-04T04:21:28Zen
dc.date.available2015-05-04T04:21:28Zen
dc.date.copyright2015en
dc.date.issued2015en
dc.identifier.citationZheng, J. (2015). Hydrogen/deuterium exchange mass spectrometry reveals distinct mechanisms of viral RNA recognition and activation by RIG-I like receptors. Doctoral thesis, Nanyang Technological University, Singapore.en
dc.identifier.urihttps://hdl.handle.net/10356/62943en
dc.description.abstractRIG-I like receptors (RLRs) are the major intracellular immune receptors that recognize viral RNA species, undergo a series of conformational transitions and activate the interferon-mediated antiviral response. However, full-length RLRs resist crystallographic efforts and a molecular description of their activation pathways remains hypothetical. Here we employ Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) to probe the apo states of RLRs and to dissect the molecular details with respect to RNA recognition, ATP hydrolysis and CARDs activation. Our data provide a high-resolution orthogonal view of RLR activation in solutions and offer new evidence for the molecular mechanism of RLR activation.en
dc.format.extent178 p.en
dc.language.isoenen
dc.subjectDRNTU::Science::Biological sciences::Biophysicsen
dc.titleHydrogen/deuterium exchange mass spectrometry reveals distinct mechanisms of viral RNA recognition and activation by RIG-I like receptorsen
dc.typeThesisen
dc.contributor.supervisorTang Kaien
dc.contributor.supervisorLiu Chuan Faen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en
dc.contributor.researchBioSciences Research Centreen
dc.identifier.doi10.32657/10356/62943en
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