Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/63295
Title: Elucidating the role of SCD1 in B cell development and function
Authors: Loo, Larry Sai Weng
Keywords: DRNTU::Science::Biological sciences::Molecular biology
Issue Date: 2015
Source: Loo, L. S. W. (2015). Elucidating the role of SCD1 in B cell development and function. Master's thesis, Nanyang Technological University, Singapore.
Abstract: Stearoyl-coenzyme A (CoA) desaturase (SCD) enzymes are a family of δ-9 fatty acid desaturases that catalyse the de novo synthesis of monounsaturated fatty acids (MUFAs) from endogenous or dietary saturated fatty acids (SFAs). Here, we reported the loss of SCD1 leads to the down-regulation of B1 cells in the peritoneal cavity, providing a further insight on the role of SCD1 in B cell development. In this case, the comparison of B cell activation markers between the C57/BL6J and Scd1ab-2J/ab-2 B cells did not reveal any distinct differences. Also, further investigations into immunoglobulin production by B cells did not reveal significant differences between the C57/BL6J and Scd1f/fCd19Cre/+mice. However, Scd1f/fCd19Cre/+mice did show significant increased frequency of antibody-secreting cells in the spleen. The study in this work should allow us to gain a further insight on SCD1 role in B cell development and functions.
URI: http://hdl.handle.net/10356/63295
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

Files in This Item:
File Description SizeFormat 
ELUCIDATING THE ROLE OF SCD1 IN B CELL DEVELOPMENT AND FUNCTION.pdf
  Restricted Access
3.15 MBAdobe PDFView/Open

Page view(s) 50

253
checked on Oct 26, 2020

Download(s) 50

17
checked on Oct 26, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.