Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/63295
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dc.contributor.authorLoo, Larry Sai Weng
dc.date.accessioned2015-05-12T04:49:26Z
dc.date.available2015-05-12T04:49:26Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationLoo, L. S. W. (2015). Elucidating the role of SCD1 in B cell development and function. Master's thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/63295
dc.description.abstractStearoyl-coenzyme A (CoA) desaturase (SCD) enzymes are a family of δ-9 fatty acid desaturases that catalyse the de novo synthesis of monounsaturated fatty acids (MUFAs) from endogenous or dietary saturated fatty acids (SFAs). Here, we reported the loss of SCD1 leads to the down-regulation of B1 cells in the peritoneal cavity, providing a further insight on the role of SCD1 in B cell development. In this case, the comparison of B cell activation markers between the C57/BL6J and Scd1ab-2J/ab-2 B cells did not reveal any distinct differences. Also, further investigations into immunoglobulin production by B cells did not reveal significant differences between the C57/BL6J and Scd1f/fCd19Cre/+mice. However, Scd1f/fCd19Cre/+mice did show significant increased frequency of antibody-secreting cells in the spleen. The study in this work should allow us to gain a further insight on SCD1 role in B cell development and functions.en_US
dc.format.extent85 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen_US
dc.titleElucidating the role of SCD1 in B cell development and functionen_US
dc.typeThesis
dc.contributor.supervisorLam Kong Pengen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degree​Master of Scienceen_US
dc.contributor.organizationA*STAR Bioprocessing Technology Instituteen_US
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