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Title: Regulation of smooth muscle cells using UV embossed microchannelled polymeric films
Authors: Shen, Jinye.
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2008
Source: Shen, J. Y. (2008). Regulation of smooth muscle cells using UV embossed microchannelled polymeric films. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic SMC is desired for cell proliferation needed for vessel remodeling but the contractile phenotype is necessary for sufficient vasoactivity and inhibition of neoinitima formation. The switch of SMC phenotype from synthetic to contractile at the appropriate cell development stage has been hypothesized to be necessary for producing a functional vascular tunica media.
Rights: Nanyang Technological University
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
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