Regulation of smooth muscle cells using UV embossed microchannelled polymeric films.
Date of Issue2008
School of Mechanical and Aerospace Engineering
The reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties and vasoactivity has yet to be demonstrated for tissue engineering of small diameter blood vessels. Synthetic SMC is desired for cell proliferation needed for vessel remodeling but the contractile phenotype is necessary for sufficient vasoactivity and inhibition of neoinitima formation. The switch of SMC phenotype from synthetic to contractile at the appropriate cell development stage has been hypothesized to be necessary for producing a functional vascular tunica media.
Nanyang Technological University