Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/64699
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dc.contributor.authorTan, Sheng Wei
dc.date.accessioned2015-05-29T06:37:35Z
dc.date.available2015-05-29T06:37:35Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10356/64699
dc.description.abstractEnvironmental enrichment (EE) has been shown to cause diverse effects, many of which affect the brain of an organism. This results in observable modifications in terms of physiology or behavior in the organism. Previous studies suggest EE influences even naturalistic hard-wired traits, such as increasing attractiveness of rats. However, molecular basis underlying this phenomenon is unknown. This study investigates this molecular basis of attractiveness by looking at two relevant systems, the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes. HPG is involved in determining attractiveness and other reproductive functions. HPA, a stress response system, exerts its influence on attractiveness through interaction with HPG axis. Dorsalmedial Ventromedial Hypothalamic Nucleus (VMHdm) and Ventrolateral Ventromedial Hypothalamic Nucleus (VMHvl) are involved in HPA and HPG respectively. Expression of an early immediate gene like C-Fos was studied using immunofluorescence, indicating activation of region of interest in the brain. In this study, we observed basal HPG tone and HPA activity in response to immobilisation stress. However, the study showed no significant difference in activation of both regions of EE rats compared to their control counterparts. This study sheds some light on the complexity of the HPG-HPA relationship and its sensitivity to the environment, paving way for future studies.en_US
dc.format.extent24 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleMolecular basis of attractivenessen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorRupshi Mitraen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeBachelor of Science in Biological Sciencesen_US
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Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)
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