Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65033
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTan, Mei Huaen
dc.date.accessioned2015-06-11T02:15:56Zen
dc.date.available2015-06-11T02:15:56Zen
dc.date.copyright2015en
dc.date.issued2015en
dc.identifier.citationTan, M. H. (2015). Regulation of differentiation by rhogtpases in mouse embryonic stem cells. Doctoral thesis, Nanyang Technological University, Singapore.en
dc.identifier.urihttps://hdl.handle.net/10356/65033en
dc.description.abstractRhoGTPases plays an essential role in the regulation of actin cytoskeleton that is important for many cellular activities in most mammalian cell types. Here, we report that RhoA, a RhoGTPase, preferentially directs cell fate specification towards endoderm and mesoderm lineages, while inhibiting ectodermal differentiation. Interestingly, our data suggest that RhoA-mediated cell fate specification is independent of ROK and mDia, the two main effectors downstream of RhoA. In addition, we have also investigated how the microenvironment can influence cell fate decision. Taken together, we have discovered a new role of RhoA in the regulation of cell fate determination during differentiation of mESCs.en
dc.format.extent136 p.en
dc.language.isoenen
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen
dc.titleRegulation of differentiation by rhogtpases in mouse embryonic stem cellsen
dc.typeThesisen
dc.contributor.supervisorKoh Cheng Geeen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en
dc.identifier.doi10.32657/10356/65033en
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:SBS Theses
Files in This Item:
File Description SizeFormat 
PhD thesis TMH 21 May 2015.pdf5.99 MBAdobe PDFThumbnail
View/Open

Page view(s) 50

255
Updated on Jan 25, 2021

Download(s) 50

85
Updated on Jan 25, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.