Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65062
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGoh, Candice Yun Si
dc.date.accessioned2015-06-11T07:00:45Z
dc.date.available2015-06-11T07:00:45Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10356/65062
dc.description.abstractThe engineering of cells using nanoparticles is a promising approach for integration free labelled cells as well as to determine the viability of the implanted cells for treatments. Particularly in the medical field, it is essential to understand the properties of nanoparticles and any possible effects on the human body before clinical use. Despite the potential nanoparticles display, limited researches are done on the toxicity of nanoparticles and little is known about the toxicity of different nanoparticles due to varying experimental controls in the studies that have been done. Therefore, it is difficult to determining whether the cytotoxicity observed is physiologically relevant. In this study, characterization of calcein-AM loaded PLGA microparticles coated with poly-l-lysine illustrates enhanced intracellular internalization. Furthermore, cytotoxicity of various and novel nanoparticles are investigated to determine an easy and safe method to quantify the viability of nanosensors. Thereafter, in vitro experiment of novel nanoparticles demonstrated that they can non-invasively determine cell viability. Hence, the study of cytotoxicity of various and novel nanoparticles is useful for identifying safe and easy methods to engineer cells for therapeutic treatments.en_US
dc.format.extent49 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Engineering::Bioengineeringen_US
dc.titleViability nanosensors to evaluate cell interaction with novel nanomaterialsen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorXu Chenjieen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.degreeBachelor of Engineering (Chemical and Biomolecular Engineering)en_US
item.grantfulltextrestricted-
item.fulltextWith Fulltext-
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)
Files in This Item:
File Description SizeFormat 
FYP Report_candice_final.pdf
  Restricted Access
1.16 MBAdobe PDFView/Open

Page view(s)

390
Updated on Jul 21, 2024

Download(s) 50

21
Updated on Jul 21, 2024

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.