Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65130
Full metadata record
DC FieldValueLanguage
dc.contributor.authorToh, Pan Shin
dc.date.accessioned2015-06-15T03:41:39Z
dc.date.available2015-06-15T03:41:39Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10356/65130
dc.description.abstractSeroma, the accumulation of fluid in vivo remains a prevalent clinical problem, as it causes complications such as infection, flap necrosis and delay in wound healing, causing great discomfort to patients. Methods used to prevent seroma formation include tacking down the skin flap and the placement of drains, and these methods have their individual advantages and disadvantages, hence, there is an idea of gluing the skin flap and adjacent tissues together with tissue adhesive to physically close up any dead space to prevent seroma from forming. Different types of tissue adhesives that are currently available include fibrin glue, cyanoacrylate adhesives and glutaraldehyde-based adhesives, but these tissues adhesives are not suitable for large-area in vivo uses to prevent seroma formation. Recent studies on protein glue secreted by marine mussels have attracted increasing attention due to its biocompatibility and great ability in wet adhesion. Although the mechanism behind the adhesion has not been completely understood, it has been found that catechol groups within are able to generate the chemisorption needed to adhere to almost all kinds of surfaces; hence, we may develop catechol group-based tissues adhesives to prevent seroma formation. In this study, a novel aldehyde-free double-crosslinked tissue adhesive is designed and developed by constituting (1) gelatin-dopamine conjugates (containing catechol groups) – as a typical gluing macromer (2) Fe3+ – as a typical rapid crosslinker; and (3) genipin – as a typical long-term acting crosslinker.en_US
dc.format.extent37 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Engineering::Bioengineeringen_US
dc.titleNovel tissue adhesive for seroma preventionen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorWang Donganen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.degreeBachelor of Engineering (Chemical and Biomolecular Engineering)en_US
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)
Files in This Item:
File Description SizeFormat 
Pan_Shin_report draft_5.pdf
  Restricted Access
670.88 kBAdobe PDFView/Open

Page view(s)

387
Updated on Jul 13, 2024

Download(s) 50

27
Updated on Jul 13, 2024

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.