Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65226
Title: Multimodal MRI-optical system for high-resolution structural and functional imaging
Authors: Vincent, Anita
Keywords: DRNTU::Engineering
Issue Date: 2015
Abstract: Near-infrared (NIR) based bioimaging modalities use electromagnetic waves in the near-infrared spectral range to study functional changes in living tissue by detecting changes in absorption, fluorescence, or scatter arising from intrinsic chromophores such as oxy- and deoxyhaemoglobin, cytochromes, metabolites etc. while Magnetic Resonance Imaging provides superior soft tissue contrast which makes it the ideal imaging modality for non-invasive visualization of brain architecture. Integrating the two modalities then creates a dual-mode imaging system that combines in vivomolecular and functional imagingwith high-quality anatomic imaging. In this research project, we set up the NIR optical setup and then worked on integrating it with the MRI scanner for simultaneous in-vivo imaging. Setup included aligning and fine-tuning the optical and electronic components as well as developing a LabVIEW based software platform to interface with each component and acquire images. The system was calibrated using DIY gelatin-based tissue phantoms for preliminary image acquisition.
URI: http://hdl.handle.net/10356/65226
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

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