Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65557
Title: A versatile, engineered cartilage platform for tissue regeneration and disease modeling
Authors: Peck, Yvonne
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2015
Source: Peck, Y. (2015). A versatile, engineered cartilage platform for tissue regeneration and disease modeling. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The articular cartilage is a load-bearing surface of synovial joints. However, it is highly susceptible to traumatic injuries and diseases. Tissue-engineering strategies offer solutions by generating engineered cartilage tissue that can fulfill two functions: in vivo cartilage regeneration and in vitro disease modeling. This thesis has employed the living hyaline cartilaginous graft (LhCG) to fulfill these functions. Chondrocyte isolation was made efficient through multiple-enzymatic digestion, improving LhCG fabrication efficiency. The as-generated LhCGs were able to regenerate cartilage over 6 months in skeletally mature pigs, assessed through radiographical, biochemical, and biomechanical tests. By placing the LhCGs in presence of other relevant cell types, osteoarthritis (OA) and rheumatoid arthritis (RA) disease progression was established. Importantly, the role of individual cells in disease pathogenesis could be studied. In summary, this thesis has demonstrated the dual function capability of LhCG for in vivo cartilage regeneration and in vitro disease modeling.
URI: https://hdl.handle.net/10356/65557
DOI: 10.32657/10356/65557
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Theses

Files in This Item:
File Description SizeFormat 
Thesis_Final_yvonne peck.pdf6.31 MBAdobe PDFThumbnail
View/Open

Page view(s) 50

284
Updated on Apr 22, 2021

Download(s) 20

233
Updated on Apr 22, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.