dc.contributor.authorPeck, Yvonne
dc.date.accessioned2015-11-12T02:59:41Z
dc.date.accessioned2017-07-23T08:26:19Z
dc.date.available2015-11-12T02:59:41Z
dc.date.available2017-07-23T08:26:19Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationPeck, Y. (2015). A versatile, engineered cartilage platform for tissue regeneration and disease modeling. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/65557
dc.description.abstractThe articular cartilage is a load-bearing surface of synovial joints. However, it is highly susceptible to traumatic injuries and diseases. Tissue-engineering strategies offer solutions by generating engineered cartilage tissue that can fulfill two functions: in vivo cartilage regeneration and in vitro disease modeling. This thesis has employed the living hyaline cartilaginous graft (LhCG) to fulfill these functions. Chondrocyte isolation was made efficient through multiple-enzymatic digestion, improving LhCG fabrication efficiency. The as-generated LhCGs were able to regenerate cartilage over 6 months in skeletally mature pigs, assessed through radiographical, biochemical, and biomechanical tests. By placing the LhCGs in presence of other relevant cell types, osteoarthritis (OA) and rheumatoid arthritis (RA) disease progression was established. Importantly, the role of individual cells in disease pathogenesis could be studied. In summary, this thesis has demonstrated the dual function capability of LhCG for in vivo cartilage regeneration and in vitro disease modeling.en_US
dc.format.extent225 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Engineering::Bioengineeringen_US
dc.titleA versatile, engineered cartilage platform for tissue regeneration and disease modelingen_US
dc.typeThesis
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.supervisorWang Donganen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SCBE)en_US
dc.identifier.doihttps://doi.org/10.32657/10356/65557


Files in this item

FilesSizeFormatView
Thesis_Final_yvonne peck.pdf6.461Mbapplication/pdfView/Open

This item appears in the following Collection(s)

Show simple item record