dc.contributor.authorAbdul Rashid Mohammad Muzaki
dc.date.accessioned2015-11-12T07:22:23Z
dc.date.accessioned2017-07-23T08:42:57Z
dc.date.available2015-11-12T07:22:23Z
dc.date.available2017-07-23T08:42:57Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationAbdul Rashid Mohammad Muzaki. (2015). Role of different dendritic cell subsets in vivo. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/65569
dc.description.abstractTo understand the roles of various gut dendritic cell (DCs) subsets in controlling intestinal inflammation, two DTR mice strains: Clec9A DTR and Clec4a4 DTR, capable of conditional in vivo ablation of respective colonic CD103+ CD11b- and CD103+ CD11b+ DCs have been generated. In a dextran sodium sulphate (DSS) model of colonic inflammation, ablation of CD103+ CD11b- colonic DCs resulted in exacerbated colitis, while ablation of colonic CD103+ CD11b+ DCs resulted in resistance to colitis when subjected to the same DSS regiment. Hence our results highlight the opposing roles of these two distinct colonic DC subsets in controlling DSS-induced colonic inflammation. A cross-talk between DCs, other gut immune cells and the colonic epithelia, involved in maintenance of a functional mucosal epithelial barrier, has been proposed to directly impact outcome of colonic inflammation. The mechanistic details of how these distinct DC subsets contribute to regulate colonic inflammation will be discussed.en_US
dc.format.extent181 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleRole of different dendritic cell subsets in vivoen_US
dc.typeThesis
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorRuedl Christianeen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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