Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/6564
Title: A structural hypothesis for the transition between bent and extended conformations of the leukocyte β2 integrins
Authors: Shi, Minlong
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2008
Source: Shi, M. (2008). A structural hypothesis for the transition between bent and extended conformations of the leukocyte β2 integrins. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: In this thesis, three fragments (PHE1, PHE2 and PHE3) of integrin beta2 subunit have been expressed and crystallized for structural and functional studies. The following solved crystal structures of the beta2 Genu in both bent (PHE2) and extended (PHE3) conformations provide a structural basis, represented by conformational changes located in the beta2 Genu.In addition, we showed that LFA-1 can be locked into a bent conformation by a disulfide bond strategically introduced between the PSI and I-EGF2 domains, the “bent” LFA-1 has the capacity for the ligand binding.
URI: https://hdl.handle.net/10356/6564
DOI: 10.32657/10356/6564
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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