Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65642
Title: Structural studies of the novel virulence factors BswR and SghA/SghR involved in pathogen virulence regulation
Authors: Ye, Fuzhou
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2015
Source: Ye, F. (2015). Structural studies of the novel virulence factors BswR and SghA/SghR involved in pathogen virulence regulation. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The pathogen-host cross-talking usually involved in different virulence factors, which play crucial roles in the pathogen virulence regulation. Here in our work, we determined crystal structures of three novel virulence factors BswR, SghA, and SghR as well as relevant complex structures. BswR mediates bacterial motilities and biofilm formation, regulates small RNA rsmZ transcription, the molecular basis for the regulation will be proposed. SghA and SghR were identified and characterized to regulate the Agrobacterium infection of plant hosts. SghR is a repressor of SghA, and negatively regulates SghA expression until the environmental signal presence. Detailed structural and functional analyses of SghA-SghR in the regulation of agrobacterial tumorigenesis and the allosteric mechanism of SghR in the regulation of SghA will be presented.
URI: http://hdl.handle.net/10356/65642
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

Files in This Item:
File Description SizeFormat 
65642 Fuhou_YE_PhD thesis_2015.pdf
  Restricted Access
7.97 MBAdobe PDFView/Open

Page view(s)

212
Updated on Nov 30, 2020

Download(s) 10

3
Updated on Nov 30, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.