Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/6564
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dc.contributor.authorShi, Minlongen
dc.date.accessioned2008-09-17T11:41:50Zen
dc.date.available2008-09-17T11:41:50Zen
dc.date.copyright2008en
dc.date.issued2008en
dc.identifier.citationShi, M. (2008). A structural hypothesis for the transition between bent and extended conformations of the leukocyte β2 integrins. Doctoral thesis, Nanyang Technological University, Singapore.en
dc.identifier.urihttps://hdl.handle.net/10356/6564en
dc.description.abstractIn this thesis, three fragments (PHE1, PHE2 and PHE3) of integrin beta2 subunit have been expressed and crystallized for structural and functional studies. The following solved crystal structures of the beta2 Genu in both bent (PHE2) and extended (PHE3) conformations provide a structural basis, represented by conformational changes located in the beta2 Genu.In addition, we showed that LFA-1 can be locked into a bent conformation by a disulfide bond strategically introduced between the PSI and I-EGF2 domains, the “bent” LFA-1 has the capacity for the ligand binding.en
dc.rightsNanyang Technological Universityen
dc.subjectDRNTU::Science::Biological sciencesen
dc.titleA structural hypothesis for the transition between bent and extended conformations of the leukocyte β2 integrinsen
dc.typeThesisen
dc.contributor.supervisorLaw Sai Kit, Alexen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en
dc.identifier.doi10.32657/10356/6564en
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