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https://hdl.handle.net/10356/6566
Title: | Studies of the molecules form plasmodium falciparum that mediate pathogenesis | Authors: | Mo, Min | Keywords: | DRNTU::Science::Biological sciences | Issue Date: | 2007 | Source: | Mo, M. (2007). Studies of the molecules form plasmodium falciparum that mediate pathogenesis. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | Adhesion of erythrocytes infected by Plasmodium falciparum to receptors of the microvasculature is a major contributor of parasite pathology and morbidity. It is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP-1) which is expressed at the surface of infected erythocytes and is linked to both antigenic variation and cytoadherence. The PfEMP-1 protein contains multiple adhesive modules, including the cysteine-rich interdomain region (CIDR). The interaction between CIDRa and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells. Here we show that a segment within the C-terminal region of CIDRa determines CD36 binding specificity. Antibodies raised against this segment can specifically block the adhesion of various parasite stains to CD36. Thus, small regions of PfEMP-1 that determine binding specificity could form suitable components of an anti-sequestration malaria vaccine effective against different parasite strains. | URI: | https://hdl.handle.net/10356/6566 | DOI: | 10.32657/10356/6566 | Schools: | School of Biological Sciences | Rights: | Nanyang Technological University | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Theses |
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SBS-THESES_13.pdf | 4.19 MB | Adobe PDF | View/Open |
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