dc.contributor.authorMo, Minen_US
dc.date.accessioned2008-09-17T11:41:55Z
dc.date.accessioned2017-07-23T08:42:06Z
dc.date.available2008-09-17T11:41:55Z
dc.date.available2017-07-23T08:42:06Z
dc.date.copyright2007en_US
dc.date.issued2007
dc.identifier.citationMo, M. (2007). Studies of the molecules form plasmodium falciparum that mediate pathogenesis. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/6566
dc.description.abstractAdhesion of erythrocytes infected by Plasmodium falciparum to receptors of the microvasculature is a major contributor of parasite pathology and morbidity. It is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP-1) which is expressed at the surface of infected erythocytes and is linked to both antigenic variation and cytoadherence. The PfEMP-1 protein contains multiple adhesive modules, including the cysteine-rich interdomain region (CIDR). The interaction between CIDRa and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells. Here we show that a segment within the C-terminal region of CIDRa determines CD36 binding specificity. Antibodies raised against this segment can specifically block the adhesion of various parasite stains to CD36. Thus, small regions of PfEMP-1 that determine binding specificity could form suitable components of an anti-sequestration malaria vaccine effective against different parasite strains.en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleStudies of the molecules form plasmodium falciparum that mediate pathogenesisen_US
dc.typeThesisen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorJulien Lescaren_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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