dc.contributor.authorMo, Minen_US
dc.identifier.citationMo, M. (2007). Studies of the molecules form plasmodium falciparum that mediate pathogenesis. Doctoral thesis, Nanyang Technological University, Singapore.
dc.description.abstractAdhesion of erythrocytes infected by Plasmodium falciparum to receptors of the microvasculature is a major contributor of parasite pathology and morbidity. It is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP-1) which is expressed at the surface of infected erythocytes and is linked to both antigenic variation and cytoadherence. The PfEMP-1 protein contains multiple adhesive modules, including the cysteine-rich interdomain region (CIDR). The interaction between CIDRa and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells. Here we show that a segment within the C-terminal region of CIDRa determines CD36 binding specificity. Antibodies raised against this segment can specifically block the adhesion of various parasite stains to CD36. Thus, small regions of PfEMP-1 that determine binding specificity could form suitable components of an anti-sequestration malaria vaccine effective against different parasite strains.en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleStudies of the molecules form plasmodium falciparum that mediate pathogenesisen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorJulien Lescaren_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US

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