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Title: Microfluidic in vitro model to study cell mechanisms and drug efficacy
Authors: Nishanth Venugopal Menon
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2015
Source: Nishanth Venugopal Menon. (2015). Microfluidic in vitro model to study cell mechanisms and drug efficacy. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Microfluidics is a platform that is being widely used for developing in-vitro models to study various in-vivo phenomena. Our aim was to develop a simple, easy to use microfluidic device, which can be used for different cell-based applications. By performing cell patterning on-a-chip we were able to develop a microfluidic in-vitro model that could be used to perform cell-cell interaction studies and cell-substrate interaction studies. The same chip was also extended to test drugs on human cells where the efficacy of a photosensitizer to perform targeted cancer cell imaging and targeted photodynamic therapy was tested. The advantage of such a system is in the fact that they can be used to perform different types of cell studies apart from facilitating drug testing and hypothesis testing.
DOI: 10.32657/10356/65723
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Theses

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